Isocoria with Constricted Pupils
Argyll-Robertson Pupil
Causes:
The precise location of the lesion is not known; presumably the dis-order is due to a lesion is in the pretectal region and the Edinger-Westphal nucleus such as tabes dorsalis (Argyll-Robertson phenomenon), encephalitis, diffuse encephalitis, syringomyelia, trauma, bleeding, tumors, and alco-holism.
Diagnostic considerations:
❖ Direct and consensual light reflexes are absent.
❖Near reflex is intact or there is overcompensation (the Edinger-Westphal nucleus is being controlled via the convergence center).
❖The pupil is not round, and constriction is not always symmetrical.
❖There is no reaction to darkness or pharmacologic stimuli.
Bilateral Pupillary Constriction due to Pharmacologic Agents
Causes:
❖ Morphine.
❖Deep general anesthesia.
❖ Pilocarpine eyedrops.
Toxic Bilateral Pupillary Constriction
Causes:
Mushroom poisoning.
Inflammatory Bilateral Pupillary Constriction
Causes:
❖ Encephalitis.
❖ Meningitis.
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